Masuda bhatti biography channel
Abstract
Ion channels are membrane-spanning integral proteins expressed in multiple organs, including the eye. In the eye, ion channels are involved in various physiological processes, like signal transmission and visual processing. A wide range of mutations have been reported in the corresponding genes and their interacting subunit coding genes, which contribute significantly to an array of blindness, termed ocular channelopathies. These mutations result in either a loss- or gain-of channel functions affecting the structure, assembly, trafficking, and localization of channel proteins. A dominant-negative effect is caused in a few channels formed by the assembly of several subunits that exist as homo- or heteromeric proteins. Here, we review the role of different mutations in switching a “sensing” ion channel to “non-sensing,” leading to ocular channelopathies like Leber’s congenital amaurosis 16 (LCA16), cone dystrophy, congenital stationary night blindness (CSNB), achromatopsia, bestrophinopathies, retinitis pigmentosa, etc. We also discuss the various in vitro and in vivo disease models available to investigate the impact of mutations on channel properties, to dissect the disease mechanism, and understand the pathophysiology. Innovating the potential pharmacological and therapeutic approaches and their efficient delivery to the eye for reversing a “non-sensing” channel to “sensing” would be life-changing.
Keywords: ocular ion channels, inherited channelopathy, disease models, nonsense mutation therapies, CRISPR-DNA/RNA editing, readthrough, anticodon engineered tRNA
1. Introduction
Ion channels are membrane-spanning transport proteins that facilitate the passive bidirectional (into and out of cell and cell organelles) flow of selective ions like sodium (Na), potassium (K), calcium (Ca), chloride (Cl), or unspecific cations (Figure 1). These ion channel proteins have an enormous heterogeneity in their electrophysiological properties. In the e
Barrister Mainul Hosein passes away
Barrister Mainul Hosein, former adviser to a caretaker government, passed away at a city hospital yesterday. He was 83.
He breathed his last while undergoing treatment at Evercare Hospital in the capital. He had been suffering from cancer, said Wahiduzzaman, an aide to Barrister Mainul.
He left behind his wife, two sons, a daughter, and a host of relatives, admirers, and well-wishers to mourn his death.
A prominent lawyer, he was a politician and publisher of The New Nation, one of the oldest English dailies in Bangladesh. He was also the former chairman of the editorial board of The Daily Ittefaq.
The eldest son of renowned journalist Tofazzal Hossain (Manik Mia), Mainul was born in Pirojpur in January 1940. After completing his graduation in 1961 from Dhaka University, he went to London to study law.
He returned to Bangladesh in 1965 and joined the Dhaka Bar Council, commencing his career in the legal field, according to his biography sent by Wahiduzzaman.
He took on the responsibility of The Daily Ittefaq as its editor in 1969, after the sudden demise of his father. Four years later, he returned to his legal profession but continued as the chairman of the board of editors.
Barrister Mainul Hosein was elected member of the parliament in 1973 from Awami League, representing his village constituency in Bhandaria of Pirojpur.
In May 1975, he and General MAG Osmani resigned from parliament after the introduction of a one-party system of government known as Baksal (Bangladesh Krishak Sramik Awami League).
He was the president of the Supreme Court Bar Association from 2000 to 2001.
Mainul served as the law, justice and parliamentary affairs adviser during his tenure in the 2007-2008 caretaker government.
In October 2018, he was arrested in a case filed by journalist Masuda Bhatti for defaming her. He spent three months in jail before he was granted bail.
Barrister Mainul's first namaz-e-janaza will be held at Baridhara
Numerical treatment for Darcy–Forchheimer flow of propylene glycol with carbon nanotubes under the impacts of MHD and activation energy
Introduction
One approach to improving heat transmission in heat exchangers is by incorporating materials with efficient thermal conductivity into the base fluid. For many years, researchers have invested significant time and effort in investigating the potential for improving heat transmission by using an integration of nanometer-scale solid particles suspended in fluids. Nevertheless, these fluids encountered several problems such as sedimentation, contaminants, corrosion, and heightened loss of pressure, among other factors. Before 1881, when Maxwell initially suggested the use of nanoparticles, there had been no notable advancement in the study of heat transmission in fluids. However, there was a significant and abrupt transformation that occurred after the year 1881. He introduced an innovative viewpoint on the behavior of mixtures of solids and fluids including nanoparticles. In their study, Masuda et al. introduced nanofluid (NF) to refer to a fluid that consists of particles that are suspended inside it, and later Choi further developed this concept. Nanofluid (NF) is a colloidal dispersion consisting of extremely small solid particles, that are 1 to 100 nm in size. Nanoparticles (NPs) have greater stability compared to larger particles such as microparticles, and they also possess the fluid region having a larger surface area in contact. NF is known for its exceptional stability and thermal conductivity. Base fluids are commonly used in industries for heat exchange, with water and ethylene glycol, and similar fluids. On the other hand, NPs are generally composed of metals like copper, aluminum, and iron, as well as carbon nanotubes (CNTs) and including their oxides. The small size of the particles reduces the potential for corrosion and pressure loss, while also enhancing the fluids’ ability to resist sedimenta .