Kaderi kibria biography sample
Open Access
Peer-reviewed
- Md. Kaderi Kibria ,
- Md. Ahad Ali,
- Md. Nurul Haque Mollah
- Md. Kaderi Kibria,
- Md. Ahad Ali,
- Md. Nurul Haque Mollah
x
Abstract
Breast cancer (BC) is yet a significant global health challenge across various populations including Ghana, though several studies on host-genome associated with BC have been investigated molecular mechanisms of BC development and progression, and candidate therapeutic agents. However, a little attention has been given on microbial genome in this regard, although alterations in microbiota and epigenetic modifications are recognized as substantial risk factors for BC. This study focused on identifying bacterial key genes (bKGs) associated with BC infections in the Ghanaian population and exploring potential drug molecules by targeting these bKGs through in silico analyses. At first, 16S rRNA bacterial sequence data were downloaded from NCBI database comprising 520 samples from BC patients and 442 from healthy controls. Analysis of 16S rRNA-Seq data showed significant differences in bacterial abundance between BC and healthy groups and identified 26 differential genera with the threshold values at |log2FC|>2.0 and p-value≤0.05. It was observed that two genera Prevotella and Anaerovibria are significantly upregulated in BC patients and others are downregulated. Functional analysis based on all differential genera identified 19 MetaCyc signaling pathways, twelve of which were significantly enriched in BC patients by containing 165 genes Top-ranked 10 genes mdh, pykF, gapA, zwf, pgi, tpiA, pgk, pfkA, ppsA, and pykA were identified as BC-causing bacterial key genes (bKGs) through protein-protein interaction network analysis. Subsequently, the bKG-guided top ranked 10 drug molecules Digitoxin, Digoxin, Ledipasvir, Suramin, Ergotamine, Venetoclax, Nilotinib, Conivaptan, Dihydroergotamine, and Elbasvir were identified using molecular docking analy Photo: Atl Aakash Veteran singer Kaderi Kibria has an illustrious career behind him. Along with making an immense contribution to Rabindra Sangeet in our country, the US-based singer has also delved into many other genres of music. Kaderi Kibria returned to the country recently, and also picked up the Ekushey Padak this year. In a conversation with The Daily Star, the veteran artiste spoke about many facets of his life. Zinga Biography ZINGA The Pioneer POP Group of Bangladesh was initially formed in 1963 by a group of young college students of Chittagong Govt. College. Zinga started its journey as the First Orchestra Band in Bangladesh. Zinga Goshty 1964 Led by Late Shafaat Ali -Zinga soon became very popular with its modern style tunes that revolutionized the Bangla POP/Band industry. Late Shafaat Ali - 1965 TV show Zinga started experimenting by blending Eastern Music in Western Style and giving Bangla Music a new flavor of fresh Breath. Zinga started playing Popular Tagore songs, Nazrul Songs & Hit movie tunes in Western Orchestra style. This group of young Bangladeshi students were the first in the country to start playing western instruments - Accordian, Drums, Guitar, Piano and modernizing Bangla Tunes. People embraced this novelty in wide open arms and Zinga Band had no problem in winning the crowd's heart. Of course Zinga faced a lot of criticism from the conservative crowd as well. But Shafaat believed that Novelty never goes uncriticized and that criticism should be viewed positively as it shows that the change has created an impact. It was the era of Rock & Roll as Elvis made his debut in the Western world. Inspired by that Shafaat dreamt of a New Era in Bangla Music World. He soon started writing Modern songs and Zinga took a leap forward from Orchestra tunes to creating POP Bangla songs. It was 1964 Shafaat's two teenage sisters Najma & Shehla Parveen stepped in the group. Both Najma & Shehla not only had outstanding vocals but was also talented of playing Piano , Bongo & the drums. And why not they grew up and got trained by Shafaat himself. Najma & Shehla - 1965 TV show Najma Zaman Playing Piano &nbs Some recent studies showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and idiopathic pulmonary fibrosis (IPF) disease might stimulate each other through the shared genes. Therefore, in this study, an attempt was made to explore common genomic biomarkers for SARS-CoV-2 infections and IPF disease highlighting their functions, pathways, regulators and associated drug molecules. At first, we identified 32 statistically significant common differentially expressed genes (cDEGs) between disease (SARS-CoV-2 and IPF) and control samples of RNA-Seq profiles by using a statistical r-package (edgeR). Then we detected 10 cDEGs (CXCR4, TNFAIP3, VCAM1, NLRP3, TNFAIP6, SELE, MX2, IRF4, UBD and CH25H) out of 32 as the common hub genes (cHubGs) by the protein-protein interaction (PPI) network analysis. The cHubGs regulatory network analysis detected few key TFs-proteins and miRNAs as the transcriptional and post-transcriptional regulators of cHubGs. The cDEGs-set enrichment analysis identified some crucial SARS-CoV-2 and IPF causing common molecular mechanisms including biological processes, molecular functions, cellular components and signaling pathways. Then, we suggested the cHubGs-guided top-ranked 10 candidate drug molecules (Tegobuvir, Nilotinib, Digoxin, Proscillaridin, Simeprevir, Sorafenib, Torin 2, Rapamycin, Vancomycin and Hesperidin) for the treatment against SARS-CoV-2 infections with IFP diseases as comorbidity. Finally, we investigated the resistance performance of our proposed drug molecules compare to the already published molecules, against the state-of-the-art alternatives publicly available top-ranked independent receptors by molecular docking analysis. Molecular docking results suggested that our proposed drug molecules would be more effective compare to the alread Magic of music
TDS: How many years has it been since you last came to Bangladesh? How does it feel to return home?
Kaderi Kibria: I came back after three years. It feels great to be back; breathing my country's air fills my soul.
TDS: How did you first become involved with music?
Kaderi Kibria: I first heard the song “Chader Hashi Baadh Bhengeche” in my father's voice. That experience kindled my love for music. I also started humming tunes from an early age. By the time I grew up, music had become everything for me. Two of my elder sisters also used to take music lessons in the evening. I used to observe their training from a distance. At one point, I learned to play the harmonium and started to sing.
TDS: What is it like to receive the Ekushey Padak?
Kaderi Kibria: I've been singing for a long time now. Everyone hopes for recognition of their good work. I've gained the admiration of many music lovers throughout the years. Now the state has also recognised my singing with the Ekushey Padak. It feels great and I will never forget this joy. I thank both the state and the current government for this honour.
TDS: Is it possible for you to practice your music regularly abroad?
Kaderi Kibria: Definitely. I believe that practice makes a man perfect. I practice usually after the Fazr prayers, as well as at night after I return home from work. I try to stay in practice as much as I can. Since there are so many Bangladeshis residing in the US now, music shows are held throughout the year. Regular performance is a great way to stay in prac Bioinformatics-based investigation on the genetic influence between SARS-CoV-2 infections and idiopathic pulmonary fibrosis (IPF) diseases, and drug repurposing